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The buildup of abnormal protein aggregates is a hallmark of ALS cases – one key protein involved in some cases of ALS is Fused in Sarcoma (FUS). A recipient of the 2024 ALS Canada-Brain Canada Discovery Grant, Dr. Guy Rouleau and his team will test if cells from people living with FUS-ALS can induce the spread of FUS protein aggregates in organoid models – small, three-dimensional brain-like structures. Their research aims to provide a better understanding of FUS pathology, providing valuable in
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