Today's mini been is here! Role of Colony Stimulating Factors in Hematopoiesis Neutrophils have a multilobed nucleus with 3-4 lobes. They contain primary, secondary, and tertiary granules, each has a different set of enzymes which help neutrophils defending us. Interleukin-3 released by the T cells act on the hemocytoblasts. The second messenger signal goes to the nucleus, the genes become active, and mitosis occurs. So, interleukin-3 acts on the hemocytoblast cells and increases the production