WEST LAFAYETTE, Ind. — Imagine that a new lifesaving medication is invented, but its unusual structure makes it difficult to manufacture. The drug might turn out to be prohibitively expensive or ...

The Lahey Clinic, Boston, Massachusetts. Sise, L. F. — Anesthetist, Lahey Clinic, and New England Baptist Hospital, Boston. Woodbridge, P. D. — Anesthetist, Lahey ...

A new synthetic strategy can catalytically access all carbene polarities with one mechanism. This mild and tuneable method reduces the complexity of forming certain cyclopropanes and offers ...

To increase the oral availability of certain therapeutic compounds, chemists will sometimes tack an ester group onto the molecule. These so-called prodrugs have a longer physiological lifetime, ...

Cyclopropanes are a common motif in medicinal chemistry. Three-carbon rings show up in drug structures for conditions including asthma, psoriasis, and COVID-19. But despite its utility, cyclopropane ...

Previously undescribed chemical process may offer safer, more practical way to create cyclopropanes—a key feature in many drugs and drug-candidates. Chemical structures called cyclopropanes can ...

Synthetic biologists have genetically tweaked soil bacteria to make compounds containing chains of three-membered rings that are so energy dense that they outmuscle advanced rocket fuel. Cyclopropanes ...

Novel series of quinoline derivatives incorporating cyclopropyl ring and sulfone linkage as substituents were synthesized, Oxidation of ethyl-2-cyclopropyl-4-(substituted phenylthio) ...