Support cells surrounding stem cells rather than stem cells alone, are far more vulnerable to ageing and may hold the key to understanding how tissues age and lose their generative capacity.

Recent research has identified a specific biological mechanism that may explain why females experience more severe ...

Research shows hair follicle aging begins in your 30s, driven by inflammation-linked gene activity detectable years before symptoms appear.

Hair loss and graying, the earliest visible hallmarks of skin aging, result from the functional decline of hair follicle stem ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Loss of the chromatin remodeller CHD3 results ...

1 School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, China 2 Queen Mary School, Nanchang University, Nanchang, China Fibroblasts are integral to the pathological ...

Bone morphogenetic protein 2 (BMP2), a key isoform within the bone morphogenetic protein family, plays a critical role in promoting angiogenesis and peripheral nerve regeneration, but its specific ...

The transforming growth factor-β (TGF-β) superfamily (TGF-β-SF) comprises over 30 cytokines, including TGF-β, activins/inhibins, bone morphogenetic proteins (BMPs), and growth differentiation factors ...

Why retinoic acid is effective in this setting but not against primary tumors, has been speculated about for nearly 50 years. Scientists resolved the mystery, showing the drug 'hijacks' a normal ...

Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10 ...

(L to R) Co-first and co-corresponding author Min Pan, PhD, co-first author Yinwen Zhang, PhD, St. Jude Department of Computational Biology, co-corresponding author John Easton, PhD, St. Jude ...