Keep up with the 2025 NFL season on FOX Sports. Prior to the final injury report, which lists players as questionable, doubtful or out, NFL teams use practice designations to update player injury statuses. This can include DNP (did not participate), LP (limited participant) or FP (full participant).

Week 17 will have some key players dealing with injuries that may affect your Fantasy Football Championship game.

Here's a closer look at the biggest NFL injuries of Week 17 and what current NFL betting lines look like for the weekend

Week 17 of the NFL season is underway, and there are some key players dealing with injuries. Here's who's in and who's out.

Trent Williams is one of the best linemen in modern NFL history, and the Sooner great suffered an injury on Sunday Night Football.

Sam Darnold and the Seahawks have won six in a row to take a one game lead into the final game of the regular season. Seattle is outscoring its opponents 29-18. Their stifling defense has allowed just 31 touchdowns through 16 games including just one last weekend in Charlotte to the Carolina Panthers in a 27-10 win.

One NFL team executive questioned whether working without an agent will continue to serve in Lamar Jackson's best interests as the star quarterback potentially heads into contract negotiations with the Baltimore Ravens this offseason.

The San Francisco 49ers will take on the Chicago Bears on Sunday night, but they'll probably have to do it without one of their best players.