Caspase and caspase-like proteases (termed metacaspases) are a conserved group of proteins that are present in multicellular and unicellular eukaryotes, as well as several prokaryotes. In the ...

Researchers have discovered using mice and human clinical specimens that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive ...

Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that ...

St. Jude Children's Research Hospital scientists have identified previously unknown functions of the enigmatic enzyme caspase-6. The findings show that caspase-6 is a key regulator of innate immunity, ...

Scientists use cell death, whether by apoptosis or necrosis, to evaluate the toxicity or effectiveness of substances of interest, including potential therapeutic agents. For example, researchers will ...

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard ...

Expression profiles associated with disease progression in non-small cell lung cancer. Background: Cisplatin is a platinum-based chemotherapeutic drug used for treating a variety of human cancers such ...

The primary interest of our lab is to investigate the molecular mechanisms of apoptosis and how they impact human health and disease. This focus has evolved to include the investigation of ...

Caspases are proteases: enzymes that catalyze the breakdown of proteins and are part of the cysteine–aspartic acid protease family. They are vital to the mechanism of programmed cell death in animals ...

Activating an executioner sounds like an unwise proposition, but the idea has produced a potent new small molecule for killing cancer cells, according to work presented at the ACS national meeting in ...